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A Novel Enantioselective Synthesis of Spiro-Oxindoles
Contributor(s): Alluri, Sesha Sridevi (Author), Wang, Chih-Hung (Author), Bertucci, Michael (Author)

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 ISBN: 3838355083     ISBN-13: 9783838355085
Publisher: LAP Lambert Academic Publishing
OUR PRICE: $50.27  

Binding Type: Paperback
Published: July 2010
Qty:
Additional Information
BISAC Categories:
- Science | Chemistry - Organic
Physical Information: 0.18" H x 6" W x 9" L (0.27 lbs) 76 pages
 
Descriptions, Reviews, Etc.
Publisher Description:
Spiro-Pyrrolidine-Oxindole is a recurring structural element that has been identified in numerous alkaloids and pharmacologically active compounds. These spiro-fused ring systems embody stereochemical and structural complexities that continue to challenge the synthetic chemist. This book describes a novel enantioselective synthesis of the spiro-pyrrolidine-oxindole ring system in a highly convergent manner.The key steps for the synthesis involve 1,3-dipolar cycloaddition reaction to form the pyrrolidine ring system and radical reaction for the formation of quarternary center. The present synthesis is efficient and would allow preparation of a library of compounds for biological screening.
 
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