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Epigenetics and Disease: Pharmaceutical Opportunities 2011 Edition
Contributor(s): Gasser, Susan M. (Editor), Li, En (Editor)

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 ISBN: 3764389885     ISBN-13: 9783764389888
Publisher: Springer
OUR PRICE: $208.99  

Binding Type: Hardcover - See All Available Formats & Editions
Published: October 2010
Qty:

Click for more in this series: Progress in Drug Research
Additional Information
BISAC Categories:
- Medical | Genetics
- Medical | Anatomy
Dewey: 611.018
LCCN: 2010937861
Series: Progress in Drug Research
Physical Information: 0.8" H x 6.3" W x 9.2" L (1.15 lbs) 270 pages
 
Descriptions, Reviews, Etc.
Publisher Description:
Epigenetics has emerged recently as an important area of molecular biological studies. Epigenetic modifications lead to potentially heritable but reversible alterations in the expression of genes that determine cell fate. Epigenetic misregulation is thus often linked to degenerative diseases, cancer and neuronal disorders. Recent biomedical interest in this regulatory system stems from the fact that epigenetic, in contrast to genetic, alterations are in principle amenable to pharmacological intervention. A few epigenetically active drugs, for example histone deacetylase inhibitors (HDACi) and DNA methyltransferase (DNMT) inhibitors, have been approved by FDA for treatment of cancers such as CTCL, MDS, and AML. This volume explores the scientific background for clinical applications of epigenetically active drugs. Included are descriptions of epigenetic controls over gene expression, the post-transcriptional silencing of genes by RNA interference (RNAi) and microRNAs, as well as new findings from stem cell research which are relevant to pharmacological applications. Content Level Research
 
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