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Introduction to Computational Proteomics Contributor(s): Yona, Golan (Author) |
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ISBN: 1584885556 ISBN-13: 9781584885559 Publisher: CRC Press
Binding Type: Hardcover - See All Available Formats & Editions Published: January 2011 Annotation: Focusing on protein classification and meta-organization, Computational Proteomics describes detailed methods for detecting self-organization in complex biological systems. This book presents the analysis of biological entities and their cellular counterparts and discusses methods for detecting the building blocks of proteins and for prediction and analysis of protein-protein interactions, expression data analysis, and pathway analysis. It also examines protein space and prediction of protein function. This book includes chapters on the analysis of protein-related data types, such as expression, as well as special chapters on Bayesian networks and their application to the protein space. Click for more in this series: Chapman & Hall/CRC Mathematical and Computational Biology |
Additional Information |
BISAC Categories: - Science | Life Sciences - Biochemistry - Science | Chemistry - Computational & Molecular Modeling - Mathematics | Applied |
Dewey: 572.6 |
Series: Chapman & Hall/CRC Mathematical and Computational Biology |
Physical Information: 1.6" H x 6.4" W x 9.3" L (2.64 lbs) 768 pages |
Features: Illustrated, Index, Table of Contents |
Review Citations: Reference and Research Bk News 04/01/2011 pg. 307 |
Descriptions, Reviews, Etc. |
Publisher Description: Introduction to Computational Proteomics introduces the field of computational biology through a focused approach that tackles the different steps and problems involved with protein analysis, classification, and meta-organization. The book starts with the analysis of individual entities and works its way through the analysis of more complex entities, from protein families to interactions, cellular pathways, and gene networks. The first part of the book presents methods for identifying the building blocks of the protein space, such as motifs and domains. It also describes algorithms for assessing similarity between proteins based on sequence and structure analysis as well as mathematical models, such as hidden Markov models and support vector machines, that are used to represent protein families and classify new instances. The second part covers methods that investigate higher order structure in the protein space through the application of unsupervised learning algorithms, such as clustering and embedding. The book also explores the broader context of proteins. It discusses methods for analyzing gene expression data, predicting protein-protein interactions, elucidating cellular pathways, and reconstructing gene networks. This book provides a coherent and thorough introduction to proteome analysis. It offers rigorous, formal descriptions, along with detailed algorithmic solutions and models. Each chapter includes problem sets from courses taught by the author at Cornell University and the Technion. Software downloads, data sets, and other material are available at biozon.org |
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