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Immunobiology and Immunopharmacology of Bacterial Endotoxins Softcover Repri Edition
Contributor(s): Szentivanyi, A. (Author), Friedman, Herman (Author)

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 ISBN: 1461293197     ISBN-13: 9781461293194
Publisher: Springer
OUR PRICE: $52.24  

Binding Type: Paperback - See All Available Formats & Editions
Published: April 2013
Qty:

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Additional Information
BISAC Categories:
- Medical | Microbiology
- Medical | Immunology
Dewey: 616.014
Series: Ettore Majorana International Science
Physical Information: 1.08" H x 7" W x 10" L (2.02 lbs) 518 pages
Features: Illustrated
 
Descriptions, Reviews, Etc.
Publisher Description:
Endotoxins are constituents of all gram negative bacteria, as well as many other microorganisms. Since their original discovery and study at the beginning and middle parts of this century, many investigations have been performed concerning their immunochemistry and physicochemistry, as well as their pharmacologic activities and physiologic effects on the host. It became widely recognized during the beginning of this century that the pyrogenicity of many microbial infections may be associated with endotoxins. Furthermore, some 80 years ago, attempts were begun to "treat" a variety of illnesses including neoplasia, with such "pyrogens", Le., bacterial endo- toxins. Inconclusive results were observed including some detrimental ones as well as, in some cases, beneficial ones. It became widely accepted that during infections with many gram negative organisms the fever occurring in patients, as well as many of the untoward pathophysiological effects of the infections, seemed to be due to the endotoxin the bacteria contained or released. In this regard, septic shock has been studied in detail by many clinicians, physiologists and pharmacologists and attempts have been made to relate the devastating effects of infection on metabolic and physiologic alterations caused by endotoxins. Recently, however, many beneficial effects of endotoxin have also been studied.
 
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