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Cap-Independent Translation Softcover Repri Edition
Contributor(s): Sarnow, Peter (Editor)

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 ISBN: 3642796656     ISBN-13: 9783642796654
Publisher: Springer
OUR PRICE: $104.49  

Binding Type: Paperback - See All Available Formats & Editions
Published: December 2011
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Additional Information
BISAC Categories:
- Medical | Infectious Diseases
- Science | Life Sciences - Biology
- Science | Life Sciences - Cell Biology
Dewey: 616.079
Series: Current Topics in Microbiology and Immmunology
Physical Information: 0.43" H x 6.14" W x 9.21" L (0.64 lbs) 183 pages
 
Descriptions, Reviews, Etc.
Publisher Description:
Whether or not an mRNA is translated is often thought to be a simple function of its steady-state concentration and the ab- sence of inhibitory proteins or RNA structures in the 5' and 3' noncoding regions. The articles presented in this volume show an unexpected flexibility of the eukaryotic translational appara- tus in the mechanism of translational initiation and provide new opportunities for regulation. Most or all mRNA molecules synthesized by RNA poly- 7 merase II in eukaryotic cells contain a 5' terminal mGpppG dinucleotide, also known as the "cap structure. " RNAs carrying a cap structure have been shown to be more resistant to attack by exoribonucleases than their uncapped counterparts. Further- more, the cap facilitates transport of the RNAs from the nucleus to the cytoplasm. In the cytoplasm, the cap functions as a binding site for the cap binding protein complex eIF-4, which enhances the translation of the RNAs by the eukaryotic trans- lational apparatus. Specifically, it has been postulated that bind- ing of e1F-4 to the 5' terminal cap facilitates the recruitment of ribosomal subunits onto the mRNAs via their free 5' ends (cap- dependent translation). Accordingly, uncapped RNAs are generally translated more poorly than capped RNAs. However, during the past 6 years both viral and cellular mRNAs have been discovered that can be translated cap-independently.
 
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