| Handbook of Molecular-Genetic Techniques for Brain and Behavior Research: Volume 13 Contributor(s): Crusio, W. E. (Editor), Gerlai, R. T. (Editor) |
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ISBN: 0444502394 ISBN-13: 9780444502391 Publisher: Elsevier Science
Binding Type: Hardcover - See All Available Formats & Editions Published: October 1999 Annotation: The book gives a broad overview of recombinant DNA techniques for the behavioral neuroscientist, with illustrative examples of applications. Species covered include rodents (mainly mice), Drosophila melanogaster, Caenorhabditis elegans and Danio rerio. Experimental techniques required to characterize the behavioral phenotypes of mutant animals is provided. Several aspects of novel molecular-genetic techniques are overviewed and possible research strategies are explained. The sections of the book start with general descriptions of techniques followed by illustrative examples. It is divided into six sections. Section 1, bioinformatics and genomics research. Section 2, top-down strategies, where the researcher starts with the phenotype and then analyzes the associated genes; bottom-up strategies, where the physiological chain leading to a phenotype is analyzed starting from the gene product. Section 3, transgenic approaches in rodents including overexpressing foreign genes and gene-targeting; systemic manipulation approaches directly targeting the central nervous system and methods used with invertebrates. Section 4, methods used to evaluate relevant behavioral phenotypes, including learning and aggression. Section 5, examples on molecular brain research in man. Section 6, ethical aspects of research in this field. Click for more in this series: Techniques in the Behavioral and Neural Sciences |
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| Additional Information |
| BISAC Categories: - Social Science | Anthropology - Physical - Medical | Neurology - Psychology | Neuropsychology |
| Dewey: 573.864 |
| LCCN: 99-38172 |
| Series: Techniques in the Behavioral and Neural Sciences |
| Physical Information: 1.69" H x 7.85" W x 10.52" L (5.42 lbs) 962 pages |
| Features: Bibliography, Illustrated, Index, Table of Contents |
| Descriptions, Reviews, Etc. |
| Publisher Description: The book gives a broad overview of recombinant DNA techniques for the behavioral neuroscientist, with illustrative examples of applications. Species covered include rodents (mainly mice), Drosophila melanogaster, Caenorhabditis elegans and Danio rerio. Experimental techniques required to characterize the behavioral phenotypes of mutant animals is provided. Several aspects of novel molecular-genetic techniques are overviewed and possible research strategies are explained. The sections of the book start with general descriptions of techniques followed by illustrative examples. It is divided into six sections. Section 1, bioinformatics and genomics research. Section 2, top-down strategies, where the researcher starts with the phenotype and then analyzes the associated genes; bottom-up strategies, where the physiological chain leading to a phenotype is analyzed starting from the gene product. Section 3, transgenic approaches in rodents including overexpressing foreign genes and gene-targeting; systemic manipulation approaches directly targeting the central nervous system and methods used with invertebrates. Section 4, methods used to evaluate relevant behavioral phenotypes, including learning and aggression. Section 5, examples on molecular brain research in man. Section 6, ethical aspects of research in this field. |
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