Power Search
Low Price Guarantee
We Take School POs
18-Methoxycoronaridine and the Habenulo-Interpeduncular Pathway
Contributor(s): Taraschenko, Olga (Author)

View larger image

 ISBN: 3639137744     ISBN-13: 9783639137743
Publisher: VDM Verlag
OUR PRICE: $69.77  

Binding Type: Paperback
Published: June 2009
Qty:
Additional Information
BISAC Categories:
- Science | Life Sciences - Biochemistry
Physical Information: 0.44" H x 6" W x 9" L (0.64 lbs) 192 pages
 
Descriptions, Reviews, Etc.
Publisher Description:
Opioid addiction is a major public health problem and the need for new efficient therapies is immense.18-Methoxycoronaridine (18-MC), an iboga alkaloid congener, has been previously shown to reduce the self-administration of several drugs of abuse, including opioids.18-MC is a potent antagonist of alpha3beta4 nicotinic receptors and this now appears to be the primary mechanism of 18- MC's action in the brain. These nicotinic receptors are present in high densities in the nuclei of the habenulo-interpeduncular pathway but not in the mesolimbic pathway, known to be involved in drug addiction.This book describes the modulation of the mesolimbic pathway by the habenulo- interpeduncular pathway during chronic exposure to opioids and examines the role of 18-MC, nicotinic receptors and acetylcholine in such modulation.This book also illustrates the contribution of the latter pathway in 18-MC's ability to attenuate opioid withdrawal.The findings described in the book provide evidence that alpha3beta4 nicotinic receptors could be a novel target for anti-addictive therapies.The monograph should be useful to pharmacologists and behavioral neuroscientists.
 
Customer ReviewsSubmit your own review
 
To tell a friend about this book, you must Sign In First!